Monolayer culture of intestinal epithelium sustains Lgr5+ intestinal stem cells
نویسندگان
چکیده
منابع مشابه
Heterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells
Intestinal stem cells (ISCs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. Lineage tracing experiments in mice have proven that ISCs can repopulate the entire intestinal crypt. It is noteworthy that in such experiments, only a subset of intestinal cr...
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Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium. Their long life, lineage plasticity, and proliferative potential underlie the necessity for tight homeostatic regulation of the ISC compartment. In that context, the guanylate cyclase C (GUCY2C) receptor and its parac...
متن کاملheterogeneity of the level of activity of lgr5+ intestinal stem cells
intestinal stem cells (iscs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. lineage tracing experiments in mice have proven that iscs can repopulate the entire intestinal crypt. it is noteworthy that in such experiments, only a subset of intestinal cr...
متن کاملYY1 is indispensable for Lgr5+ intestinal stem cell renewal.
The intestinal stem cell fuels the highest rate of tissue turnover in the body and has been implicated in intestinal disease and cancer; understanding the regulatory mechanisms controlling intestinal stem cell physiology is of great importance. Here, we provide evidence that the transcription factor YY1 is essential for intestinal stem cell renewal. We observe that YY1 loss skews normal homeost...
متن کاملIntact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.
Lifelong self-renewal of the adult intestinal epithelium requires the activity of stem cells located in mucosal crypts. Lgr5 and Bmi1 are two molecular markers of crypt-cell populations that replenish all lineages over time and hence function as stem cells. Intestinal stem cells require Wnt signaling, but the understanding of their cellular niche is incomplete. Lgr5-expressing crypt base column...
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ژورنال
عنوان ژورنال: Cell Discovery
سال: 2018
ISSN: 2056-5968
DOI: 10.1038/s41421-018-0036-z